Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713162 | 0.89 | CNR1 (0.44) | TP53KMT2AMEN1CNR1 | |
| SCHEMBL12713082 | 0.83 | ALDH1A1 (0.47) | GPR119MAPTKDM4ETP53TDP1 | |
| SCHEMBL13948343 | 0.79 | TP53 (0.44) | MAPTTP53KMT2AMEN1CNR1 | |
| SCHEMBL13940957 | 0.79 | TP53 (0.44) | MAPTTP53KMT2AMEN1CNR1 | |
| SCHEMBL19013246 | 0.77 | GPR119 (0.55) | GPR119MAPTKDM4ETHRBTP53 | |
| SCHEMBL17305168 | 0.77 | GPR119 (0.46) | GPR119MAPTKDM4ETHRBTP53 | |
| SCHEMBL12713081 | 0.76 | GPR119 (0.57) | GPR119MAPTKDM4ETHRBTP53 | |
| SCHEMBL5101747 | 0.75 | GPR119 (0.51) | GPR119MAPTKDM4ETHRBTP53 | |
| SCHEMBL12713199 | 0.75 | SMN1; SMN2 (0.45) | MAPTTP53KMT2AMEN1CNR1 | |
| SCHEMBL3549233 | 0.74 | GPR119 (0.55) | GPR119MAPTKDM4ETHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015867-A1 | SUBSTITUTED ARYL OR HETEROARYLPIPERDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-02-05 | — | — | WO | disclosed |