Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 16/20 | 0.75 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.75 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14075264 | 0.96 | PLK1 (0.69) | PLK1PLK3KCNK2MEN1PKM | |
| SCHEMBL14075262 | 0.87 | SMN1; SMN2 (0.62) | PLK1PLK3KCNK2MEN1PKM | |
| SCHEMBL14075266 | 0.83 | PLK1 (0.78) | PLK1PLK3MEN1PKMKMT2A | |
| SCHEMBL14075419 | 0.83 | PLK1 (0.55) | PLK1PLK3KCNK2MEN1PKM | |
| SCHEMBL28808948 | 0.83 | PLK1 (0.97) | PLK1PLK3 | |
| SCHEMBL1308714 | 0.82 | MEN1 (0.76) | KCNK2MEN1PKMKMT2ANPSR1 | |
| SCHEMBL3366850 | 0.81 | KCNK2 (1.00) | PLK1PLK3KCNK2MEN1KMT2A | |
| SCHEMBL29862876 | 0.81 | KCNK2 (1.00) | PLK1PLK3KCNK2MEN1KMT2A | |
| SCHEMBL3366853 | 0.81 | KCNK2 (1.00) | PLK1PLK3KCNK2MEN1KMT2A | |
| SCHEMBL10339426 | 0.80 | SERPINE1 (0.69) | PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |