Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13941747 | 0.87 | MEN1 (0.75) | PLK1MEN1KMT2APKMNPSR1 | |
| SCHEMBL14075222 | 0.83 | SERPINE1 (0.67) | PLK1MEN1KMT2APKMNPSR1 | |
| SCHEMBL14075268 | 0.83 | PLK1 (0.75) | PLK1MEN1KMT2APKMNPSR1 | |
| SCHEMBL14075264 | 0.81 | PLK1 (0.69) | PLK1MEN1KMT2APKMNPSR1 | |
| SCHEMBL8027782 | 0.81 | PLK1 (0.93) | PLK1MEN1KMT2ANR1H4PLK3 | |
| SCHEMBL1308442 | 0.81 | KMT2A (1.00) | MEN1KMT2APKMNPSR1KDM4E | |
| SCHEMBL1308714 | 0.79 | MEN1 (0.76) | MEN1KMT2APKMNPSR1NR1H4 | |
| SCHEMBL6353181 | 0.79 | AKR1C2 (0.77) | PLK1MEN1KMT2ANR1H4PLK3 | |
| SCHEMBL1307943 | 0.78 | SERPINE1 (0.70) | PLK1MEN1KMT2APKMNPSR1 | |
| SCHEMBL14075251 | 0.78 | PLK1 (0.72) | PLK1NR1H4PLK3TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |