Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 5/20 | 0.40 |
| ▸ | CALCA | P06881 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | UGCG | Q16739 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13948017 | 0.89 | MC4R (0.38) | MC4RCALCACYP3A4UGCGPROKR1 | |
| SCHEMBL13941155 | 0.88 | MC4R (0.39) | MC4RCALCAOPRM1OPRD1EPHX2 | |
| SCHEMBL14435581 | 0.87 | UGCG (0.42) | MC4RCALCACYP3A4UGCGPROKR1 | |
| SCHEMBL12713076 | 0.84 | CALCA (0.46) | MC4RCALCACYP3A4UGCGF10 | |
| SCHEMBL12738196 | 0.82 | MC4R (0.52) | MC4RCALCACYP3A4UGCGF10 | |
| SCHEMBL12713085 | 0.82 | CALCA (0.46) | MC4RCALCACYP3A4UGCGOPRM1 | |
| SCHEMBL12713306 | 0.81 | HDAC8 (0.48) | MC4REPHX2 | |
| SCHEMBL12713302 | 0.81 | CALCA (0.42) | MC4RCALCACYP3A4UGCGF10 | |
| SCHEMBL14435958 | 0.81 | CYP1A2 (0.41) | MC4RPROKR1F10EPHX2 | |
| SCHEMBL13940673 | 0.81 | EPHX2 (0.41) | F10EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009015867-A1 | SUBSTITUTED ARYL OR HETEROARYLPIPERDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-02-05 | — | — | WO | disclosed |