Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.64 |
| ▸ | MEN1 | O00255 | 10/20 | 0.64 |
| ▸ | LMNA | P02545 | 7/20 | 0.64 |
| ▸ | GAA | P10253 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | TEX264 | Q9Y6I9 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | DDX3X | O00571 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13091225 | 0.86 | KMT2A (0.84) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL22737807 | 0.81 | MAPT (0.68) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL27776229 | 0.81 | MAPT (0.58) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL1659816 | 0.80 | MAPT (0.62) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL1659812 | 0.80 | MAPT (0.62) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL13883261 | 0.80 | CTSS (0.60) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL13091224 | 0.79 | KMT2A (0.71) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL13942700 | 0.79 | MAPT (0.55) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL13100734 | 0.79 | MAPT (0.62) | MAPTKMT2AMEN1LMNAGAA | |
| SCHEMBL8909361 | 0.78 | CTSS (0.63) | MAPTKMT2AMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194783-B1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2009023558-A1 | COMPOSITIONS AND METHODS FOR APOPTOSIS MODULATORS | VM DISCOVERY INC. (US) | 2009-02-19 | — | — | WO | disclosed |