SCHEMBL757098

SCHEMBL757098

C(=Cc1ccc(Nc2nc(Nc3ccccc3)nc(N3CCOCC3)n2)cc1)c1ccc(Nc2nc(Nc3ccccc3)nc(N3CCOCC3)n2)cc1

nearest known ligand 0.77

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.77
HTT P42858 1/20 0.77
POLB P06746 3/20 0.67
CA12 O43570 3/20 0.67
CA1 P00915 3/20 0.67
CA2 P00918 3/20 0.67
CA9 Q16790 3/20 0.67
MAPT P10636 5/20 0.65
SMN1; SMN2 Q16637 2/20 0.61
CYP1A2 P05177 1/20 0.61
CYP3A4 P08684 1/20 0.61
CYP2C9 P11712 1/20 0.61
CYP2C19 P33261 1/20 0.61
TP53 P04637 1/20 0.60
KMT2A Q03164 5/20 0.57
MEN1 O00255 3/20 0.57
PTGS2 P35354 2/20 0.57
NPSR1 Q6W5P4 2/20 0.56
GAA P10253 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3115297 1.00 LMNA (0.77) LMNAHTTPOLBCA12CA1
SCHEMBL30139086 1.00 LMNA (0.77) LMNAHTTPOLBCA12CA1
SCHEMBL1735430 0.99 LMNA (0.75) LMNAHTTPOLBCA12CA1
SCHEMBL8925967 0.99 LMNA (0.75) LMNAHTTPOLBCA12CA1
SCHEMBL3880764 0.99 LMNA (0.75) LMNAHTTPOLBCA12CA1
SCHEMBL29345146 0.90 LMNA (0.94) LMNAHTTPOLBCA12CA1
SCHEMBL11810697 0.87 LMNA (1.00) LMNAHTTPOLBCA12CA1
SCHEMBL18796549 0.87 LMNA (0.65) LMNAHTTPOLBCA12CA1
SCHEMBL6740369 0.85 LMNA (0.78) LMNAHTTPOLBCA12CA1
SCHEMBL11876083 0.85 PTGS2 (0.62) LMNAHTTPOLBCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 613 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2976415-B1 COLOUR PROTECTING DETERGENT COMPOPOSITION COMPRISING AN OPTICAL BRIGHTENER HENKEL AG & CO KGAA (DE) 2018-10-17 EP claimed
US-20150064773-A1 Detergent Composition and Substitution of Optical Brighteners in Detergent Composition NOVOZYMES AS (DK) 2015-03-05 US claimed
EP-2823026-A1 DETERGENT COMPOSITION AND SUBSTITUTION OF OPTICAL BRIGHTENERS IN DETERGENT COMPOSITIONS Novozymes A/S (DK) 2015-01-14 EP claimed
WO-2013131964-A1 DETERGENT COMPOSITION AND SUBSTITUTION OF OPTICAL BRIGHTENERS IN DETERGENT COMPOSITIONS NOVOZYMES A/S (DK) 2013-09-12 WO claimed
EP-1555009-B1 Skin make-up composition OREAL (FR) 2010-07-14 EP claimed
US-20050175562-A1 crosslinked organopolysiloxane having dimethylvinylsiloxy end groups and a methylhydropolysiloxane having trimethylsiloxy end groups; water, oil, water soluble sovlent as liquid binder; and goniochromatic / photochromic or fluorescent coloring agents; cosmetic L'OREAL S.A. (FR) 2005-08-11 US claimed
EP-3478827-B1 LIPASE VARIANTS AND COMPOSITIONS COMPRISING SURFACTANT AND LIPASE VARIANT NOVOZYMES AS (DK) 2024-06-19 EP disclosed
WO-2024121070-A1 PROTEASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME NOVOZYMES A/S (DK) 2024-06-13 WO disclosed
US-20240150743-A1 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME NOVOZYMES A/S (DK) 2024-05-09 US disclosed
EP-3583155-B1 ROOM-TEMPERATURE-CURABLE SILICONE COMPOSITION AND ELECTRIC/ELECTRONIC APPARATUS DOW SILICONES CORP (US) 2024-05-08 EP disclosed
US-20240141258-A1 DETERGENT COMPOSITIONS COMPRISING BACTERIAL MANNANASES AB ENZYMES FINLAND OY (FI) 2024-05-02 US disclosed
US-20240132807-A1 SUBTILASE VARIANTS NOVOZYMES A/S (DK) 2024-04-25 US disclosed
US-20240124806-A1 LIPASE VARIANTS AND COMPOSITIONS COMPRISING SURFACTANT AND LIPASE VARIANT NOVOZYMES A/S (DK) 2024-04-18 US disclosed
US-20050175562-A1 crosslinked organopolysiloxane having dimethylvinylsiloxy end groups and a methylhydropolysiloxane having trimethylsiloxy end groups; water, oil, water soluble sovlent as liquid binder; and goniochromatic / photochromic or fluorescent coloring agents; cosmetic L'OREAL S.A. (FR) 2005-08-11 US disclosed
US-20040241115-A1 Nail varnish composition comprising fibers covered with at least one fluorescent whitening agent L'OREAL S.A. (FR) 2004-12-02 US disclosed
CN-1334858-A Process for producing particles of amine reaction product PROCTER & GAMBLE (US) 2002-02-06 CN disclosed
EP-0414463-B1 Laundry treatment product UNILEVER PLC (GB) 1996-01-03 EP disclosed
EP-0167205-B1 STABLE LIQUID DETERGENTS CONTAINING ANIONIC SURFACTANT AND MONOSULFONATED BRIGHTENER THE PROCTER & GAMBLE COMPANY (US) 1992-03-11 EP disclosed
EP-0167205-A2 Stable liquid detergents containing anionic surfactant and monosulfonated brightener THE PROCTER & GAMBLE COMPANY (US) 1986-01-08 EP disclosed
US-4559169-A STILBENE SULFONATE DERIVATIVES THE PROCTER & GAMBLE COMPANY (US) 1985-12-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040241115-A1 Nail varnish composition comprising fibers covered with at least one fluorescent whitening agent POLR1C, NACA, DPM1 LMNA 1452/4885HTT 359/4885POLB 326/4885
US-20050175562-A1 crosslinked organopolysiloxane having dimethylvinylsiloxy end groups and a methylhydropolysiloxane having trimethylsiloxy end groups; water, oil, water soluble sovlent as liquid binder; and goniochromatic / photochromic or fluorescent coloring agents; cosmetic MICA, MITF, CUTA LMNA 468/4885HTT 392/4885POLB 422/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.