Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 11/20 | 0.59 |
| ▸ | CCR4 | P51679 | 2/20 | 0.52 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942959 | 0.90 | PIK3CA (0.64) | PIK3CAKDM4EHTR2CCCR4 | |
| SCHEMBL13944733 | 0.88 | PIK3CA (0.83) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13946788 | 0.88 | PIK3CA (0.61) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13942984 | 0.85 | HTR2C (0.82) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13942960 | 0.85 | HTR2C (0.77) | PIK3CAKDM4EMEN1CYP1A2POLB | |
| SCHEMBL13947204 | 0.81 | HTR2C (0.58) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13943676 | 0.81 | KDM4E (0.62) | PIK3CAKDM4EMEN1CYP1A2POLB | |
| SCHEMBL13947567 | 0.80 | HTR2C (0.71) | PIK3CAKDM4EMEN1CYP1A2POLB | |
| SCHEMBL2861107 | 0.79 | HTR2C (0.85) | PIK3CAHTR2CBCDIN3D | |
| SCHEMBL13944184 | 0.79 | PDE2A (0.59) | HTR2CCCR4BCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |