Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.64 |
| ▸ | HTR2C | P28335 | 11/20 | 0.60 |
| ▸ | CCR4 | P51679 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942985 | 0.90 | PIK3CA (0.62) | PIK3CAHTR2CCCR4KDM4E | |
| SCHEMBL13946788 | 0.88 | PIK3CA (0.61) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13944733 | 0.88 | PIK3CA (0.83) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13942984 | 0.85 | HTR2C (0.82) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13942986 | 0.85 | CTNNB1 (0.48) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13947204 | 0.84 | HTR2C (0.58) | PIK3CAHTR2CCCR4 | |
| SCHEMBL13947359 | 0.81 | HTR2C (0.62) | PIK3CAHTR2CLMNAKDM4E | |
| SCHEMBL2857218 | 0.79 | PIK3CA (0.74) | PIK3CAHTR2C | |
| SCHEMBL13944361 | 0.78 | PIK3CA (1.00) | PIK3CAHTR2C | |
| SCHEMBL13944754 | 0.77 | HTR2C (0.53) | PIK3CAHTR2CCCR4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |