Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 13/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943325 | 0.89 | HTR2C (0.65) | HTR2CPIK3CATP53MAPK14 | |
| SCHEMBL13942984 | 0.84 | HTR2C (0.82) | HTR2CPIK3CACCR4 | |
| SCHEMBL13942959 | 0.84 | PIK3CA (0.64) | HTR2CPIK3CACCR4 | |
| SCHEMBL13944754 | 0.82 | HTR2C (0.53) | HTR2CPIK3CACCR4 | |
| SCHEMBL13943326 | 0.81 | HTR2C (0.68) | HTR2CPIK3CATP53 | |
| SCHEMBL13942985 | 0.81 | PIK3CA (0.62) | HTR2CPIK3CACCR4 | |
| SCHEMBL13944733 | 0.80 | PIK3CA (0.83) | HTR2CPIK3CACCR4 | |
| SCHEMBL13946788 | 0.80 | PIK3CA (0.61) | HTR2CPIK3CACCR4 | |
| SCHEMBL13943704 | 0.80 | HTR2C (0.60) | HTR2CPIK3CATP53 | |
| SCHEMBL13942986 | 0.78 | CTNNB1 (0.48) | HTR2CPIK3CACCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |