Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PDE2A | O00408 | 2/20 | 0.50 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946815 | 0.90 | HTR2C (0.72) | HTR2CKDM4EMAPTNPSR1MAPK1 | |
| SCHEMBL13943327 | 0.89 | TP53 (0.60) | HTR2CTP53PDE2AKMT2AHRH4 | |
| SCHEMBL13946789 | 0.89 | TP53 (0.59) | HTR2CTP53PDE2AHRH4PDE5A | |
| SCHEMBL13943321 | 0.87 | TP53 (0.65) | HTR2CTP53PDE2ABCDIN3DHRH4 | |
| SCHEMBL13942993 | 0.85 | HTR2C (0.74) | HTR2CTP53KDM4EMAPTNPSR1 | |
| SCHEMBL13943298 | 0.82 | HTR2C (0.61) | HTR2CKDM4EMAPTNPSR1MAPK1 | |
| SCHEMBL13944749 | 0.81 | TP53 (0.56) | HTR2CTP53PDE2ABCDIN3D | |
| SCHEMBL13944192 | 0.81 | HTR2C (0.60) | HTR2CKDM4EMAPTNPSR1MAPK1 | |
| SCHEMBL13942987 | 0.81 | PDE2A (0.66) | HTR2CTP53PDE2AKMT2ACYP1A2 | |
| SCHEMBL13946820 | 0.81 | HTR2C (0.70) | HTR2CPDE2AHTTHRH4PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |