Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 13/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943327 | 0.91 | TP53 (0.60) | TP53HTR2CPDE2AATAD2PIK3CA | |
| SCHEMBL13943321 | 0.89 | TP53 (0.65) | TP53HTR2CPDE2APIK3CAHRH4 | |
| SCHEMBL13943310 | 0.89 | HTR2C (0.65) | TP53HTR2CPDE2APDE5AHRH4 | |
| SCHEMBL13944749 | 0.83 | TP53 (0.56) | TP53HTR2CPDE2APIK3CA | |
| SCHEMBL13942987 | 0.80 | PDE2A (0.66) | TP53HTR2CPDE2ABRD4 | |
| SCHEMBL13943712 | 0.79 | PDE2A (0.63) | TP53HTR2CPDE2ABRD4 | |
| SCHEMBL13942977 | 0.79 | PDE2A (0.69) | TP53HTR2CPDE2AATAD2PDE5A | |
| SCHEMBL13943298 | 0.78 | HTR2C (0.61) | HTR2CPDE2APDE5AHRH4 | |
| SCHEMBL13946815 | 0.78 | HTR2C (0.72) | HTR2CPDE2APDE5AHRH4 | |
| SCHEMBL13946800 | 0.77 | HTR2C (0.60) | TP53HTR2CPDE2AATAD2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |