Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 13/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946789 | 0.91 | TP53 (0.59) | TP53HTR2CPDE2AATAD2PIK3CA | |
| SCHEMBL13943321 | 0.90 | TP53 (0.65) | TP53HTR2CPDE2APIK3CAHRH4 | |
| SCHEMBL13943310 | 0.89 | HTR2C (0.65) | TP53HTR2CPDE2AKMT2APDE5A | |
| SCHEMBL13942987 | 0.89 | PDE2A (0.66) | TP53HTR2CPDE2AKMT2A | |
| SCHEMBL13943298 | 0.87 | HTR2C (0.61) | HTR2CPDE2APDE5AHRH4 | |
| SCHEMBL13943704 | 0.85 | HTR2C (0.60) | TP53HTR2CPIK3CA | |
| SCHEMBL13944749 | 0.84 | TP53 (0.56) | TP53HTR2CPDE2APIK3CA | |
| SCHEMBL13946796 | 0.81 | HTR2C (0.58) | HTR2CKMT2APIK3CA | |
| SCHEMBL13947041 | 0.81 | HTR2C (0.62) | TP53HTR2CPDE2AHRH4 | |
| SCHEMBL13947035 | 0.81 | PDE2A (0.64) | TP53HTR2CPDE2AHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| EP-2025678-A1 | Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase | Oncalis AG (CH) | 2009-02-18 | — | — | EP | disclosed |