Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 10/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13942977 | 0.91 | PDE2A (0.69) | PDE2AHTR2CTP53 | |
| SCHEMBL13943712 | 0.90 | PDE2A (0.63) | PDE2AHTR2CTP53BRD4 | |
| SCHEMBL13943327 | 0.89 | TP53 (0.60) | PDE2AHTR2CTP53KMT2A | |
| SCHEMBL13943722 | 0.87 | PDE2A (0.67) | PDE2AHTR2CTP53BRD4ABL1 | |
| SCHEMBL13943298 | 0.86 | HTR2C (0.61) | PDE2AHTR2C | |
| SCHEMBL13947035 | 0.84 | PDE2A (0.64) | PDE2AHTR2CTP53 | |
| SCHEMBL13943310 | 0.81 | HTR2C (0.65) | PDE2AHTR2CTP53KMT2ACYP1A2 | |
| SCHEMBL13946789 | 0.80 | TP53 (0.59) | PDE2AHTR2CTP53BRD4 | |
| SCHEMBL13946796 | 0.80 | HTR2C (0.58) | HTR2CKMT2A | |
| SCHEMBL13947041 | 0.80 | HTR2C (0.62) | PDE2AHTR2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009023978-A1 | PYRAZOLO [3,4 -D] PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF PROTEIN KINASE | ONCALIS AG (CH) | 2009-02-26 | — | — | WO | disclosed |