Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946565 | 0.87 | MAOA (0.44) | MAOACASP1GAATSHRALDH1A1 | |
| SCHEMBL13946568 | 0.78 | SLC2A1 (0.51) | ALDH1A1 | |
| SCHEMBL12935923 | 0.77 | ALOX5 (0.44) | ALDH1A1HTR1A | |
| SCHEMBL13946562 | 0.77 | SCN1A (0.62) | TSHRPDE4DALDH1A1HTR1AMAPK1 | |
| SCHEMBL18287910 | 0.75 | MAOA (0.50) | MAOACASP1GAATSHRPDE4B | |
| SCHEMBL2082072 | 0.74 | CNR1 (0.40) | ALDH1A1LMNACNR1CNR2HDAC3 | |
| SCHEMBL13242104 | 0.74 | SLC6A4 (0.36) | LMNAHTR7 | |
| SCHEMBL14778726 | 0.74 | OPRM1 (0.45) | TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL11833439 | 0.73 | CHRNA7 (0.36) | MAOACASP1GAATSHRPDE4B | |
| SCHEMBL2084317 | 0.73 | CNR1 (0.40) | ALDH1A1LMNACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030056-A1 | NOVEL SODIUM CHANNEL BLOCKERS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-01-29 | — | — | US | disclosed |
| US-7439383-B2 | Sodium channel blockers | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030056-A1 | NOVEL SODIUM CHANNEL BLOCKERS | SCNN1B, SCN1B, KCNN2 | MAOA 2380/4885CASP1 2462/4885GAA 4705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.