Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 7/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947599 | 0.86 | CXCR2 (0.38) | CXCR2 | |
| SCHEMBL13948283 | 0.86 | KMT2A (0.30) | KMT2A | |
| SCHEMBL13208089 | 0.85 | CXCR1 (0.46) | CXCR2CXCR1 | |
| SCHEMBL14621569 | 0.84 | OPRK1 (0.33) | CXCR2CXCR1OPRK1OPRM1KCNH2 | |
| SCHEMBL14100257 | 0.84 | — | — | |
| SCHEMBL13947453 | 0.83 | CXCR2 (0.40) | CXCR2CXCR1OPRK1OPRM1KMT2A | |
| SCHEMBL13207239 | 0.82 | CXCR2 (0.46) | CXCR2CXCR1TP53MAPT | |
| SCHEMBL14100160 | 0.80 | ROCK2 (0.37) | OPRK1OPRM1KCNH2KMT2AMAPT | |
| SCHEMBL13208116 | 0.79 | CXCR2 (0.45) | CXCR2CXCR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13947697 | 0.78 | CXCR2 (0.53) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551818-B1 | THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2009-02-04 | — | — | EP | disclosed |
| EP-1694659-B1 | THIADIAZOLES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS | SCHERING CORP (US) | 2008-08-27 | — | — | EP | disclosed |