Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.39 |
| ▸ | CCND1 | P24385 | 3/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13950173 | 0.89 | P2RX7 (0.40) | HTR6HTR2BHSD11B1GRM2 | |
| SCHEMBL20780483 | 0.89 | HTR6 (0.49) | HTR6HTR2BCDK4CCND1LDHA | |
| SCHEMBL13950174 | 0.86 | HTR2B (0.38) | HTR6HTR2B | |
| SCHEMBL13950161 | 0.84 | HTR2B (0.45) | HTR2BHSD11B1 | |
| SCHEMBL13950164 | 0.83 | HTR6 (0.42) | HTR6HTR2BCDK4CCND1HSD11B1 | |
| SCHEMBL16181071 | 0.81 | HTR6 (0.47) | HTR6CDK4CCND1HSD11B1LDHA | |
| SCHEMBL13950163 | 0.81 | HTR6 (0.46) | HTR6HTR2BHSD11B1GRM2 | |
| SCHEMBL13950176 | 0.80 | GAA (0.41) | HTR2B | |
| SCHEMBL13950172 | 0.77 | SRD5A1 (0.39) | HTR2BCDK4CCND1HSD11B1GRM2 | |
| SCHEMBL17446671 | 0.77 | HTR2B (0.39) | HTR6HTR2BCDK4CCND1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865707-B2 | Cholesteryl ester transfer protein inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | MERCK SHARP & DOHME LLC | 2009-01-15 | — | — | US | disclosed |
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | MERCK SHARP & DOHME LLC | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | CETP, APOB, MTTP | HTR6 4355/4885HTR2B 3816/4885CDK4 3847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.