Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TYMP | P19971 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26110328 | 0.89 | ADH5 (0.37) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL17303461 | 0.79 | RXFP1 (0.40) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL1230218 | 0.78 | METAP2 (0.44) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL1653225 | 0.78 | SMN1; SMN2 (0.39) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL1825663 | 0.78 | NPC1 (0.48) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL444271 | 0.78 | RPA1 (0.48) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL2968301 | 0.78 | ATM (0.48) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL4224606 | 0.78 | KDM4E (0.47) | NPC1RAB9ATP53BCL2L1 | |
| SCHEMBL1115394 | 0.78 | S1PR1 (0.38) | — | |
| SCHEMBL2655553 | 0.77 | NPC1 (0.46) | NPC1RAB9AMAPTNFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112198309-A | Chemiluminescence substrate detection kit with high sensitivity and stable signal | 上海雅酶生物医药科技有限公司 | 2021-01-08 | — | — | CN | disclosed |
| CN-105062502-B | Liquid-crystal compounds and its preparation method and use containing penta azacyclo | 华南师范大学 | 2017-08-25 | — | — | CN | disclosed |
| CN-105062502-A | Liquid crystal compound containing five membered nitrogen-containing heterocycles, as well as synthesizing method and application thereof | UNIV SOUTH CHINA NORMAL | 2015-11-18 | — | — | CN | disclosed |
| EP-2078009-B1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI SA (FR) | 2015-03-18 | — | — | EP | disclosed |
| CN-102435598-B | Stable HRP enzymatic enhanced chemiluminescent substrate solution | BIOBASE BIODUSTRY SHANDONG CO | 2013-07-10 | — | — | CN | disclosed |
| EP-2313412-B1 | NOVEL DERIVATIVES OF PYRROLOINDOLE INHIBITORS OF HSP90, COMPOSITIONS CONTAINING SAME, AND USE THEREOF | SANOFI SA (FR) | 2013-01-02 | — | — | EP | disclosed |
| US-8309721-B2 | HSP90 inhibitory carbazole derivatives, compositions containing same and use thereof | SANOFI (FR) | 2012-11-13 | — | — | US | disclosed |
| US-8178687-B2 | Derivatives of pyrroloindole which are inhibitors of Hsp90, compositions containing same, and use thereof | SANOFI-AVENTIS (FR) | 2012-05-15 | — | — | US | disclosed |
| CN-102439003-A | Indazole derivatives inhibiting HSP90, compositions containing said derivatives and uses thereof | SANOFI AVENTIS | 2012-05-02 | — | — | CN | disclosed |
| CN-102435598-A | Stable HRP enzymatic enhanced chemiluminescent substrate solution | BIOBASE BIODUSTRY SHANDONG CO | 2012-05-02 | — | — | CN | disclosed |
| CN-101528735-A | Novel fluorene derivatives, compositions containing them and use as chaperone protein HSP90 inhibitors | SANOFI AVENTIS (FR) | 2009-09-09 | — | — | CN | disclosed |
| EP-2078009-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | Sanofi-Aventis (FR) | 2009-07-15 | — | — | EP | disclosed |
| WO-2009004146-A2 | NOVEL HERBIMYCIN A ANALOGUE DERIVATIVES, COMPOSITIONS CONTAINING SAME AND USE THEREOF | SANOFI-AVENTIS (FR) | 2009-01-08 | — | — | WO | disclosed |
| EP-1654254-A4 | ANTIFUNGAL AZOLE DERIVATIVES HAVING A FLUOROVINYL MOIETY AND PROCESS FOR THE PREPARATION THEREOF | KOREA RES INST CHEM TECH (KR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2008049994-A1 | NEW FLUORENE DERIVATIVES, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF AS INHIBITORS OF THE PROTEIN CHAPERONE HSP 90 | SANOFI-AVENTIS (FR) | 2008-05-02 | — | — | WO | disclosed |
| US-20080027117-A1 | Antifungal Azole Derivatives Having a Fluorovinyl Moiety and Process for the Preparation Thereof | KOREA RESERACH INSTIITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-01-31 | — | — | US | disclosed |
| EP-1654254-A1 | ANTIFUNGAL AZOLE DERIVATIVES HAVING A FLUOROVINYL MOIETY AND PROCESS FOR THE PREPARATION THEREOF | Korea Research Institute of Chemical Technology (KR) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014583-A1 | ANTIFUNGAL AZOLE DERIVATIVES HAVING A FLUOROVINYL MOIETY AND PROCESS FOR THE PREPARATION THEREOF | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2005-02-17 | — | — | WO | disclosed |
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027117-A1 | Antifungal Azole Derivatives Having a Fluorovinyl Moiety and Process for the Preparation Thereof | ERG28, CYP51A1, CYP4F8 | MEN1 140/4885KMT2A 700/4885NPC1 198/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.