Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 9/20 | 0.43 |
| ▸ | AURKA | O14965 | 5/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 7/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | NRAS | P01111 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13954586 | 0.86 | AURKB (0.49) | AURKBAURKAFLT3SYKCHEK1 | |
| SCHEMBL13954830 | 0.73 | AURKB (0.47) | AURKBAURKAMAPKAPK5PTK6FLT3 | |
| SCHEMBL13954832 | 0.72 | AURKB (0.68) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL14538480 | 0.72 | AURKB (0.49) | AURKBAURKAMAPKAPK5PTK6LCK | |
| SCHEMBL13954947 | 0.69 | AURKB (0.47) | AURKBAURKAMAPKAPK5PTK6FLT3 | |
| SCHEMBL14536797 | 0.68 | AURKB (0.50) | AURKBAURKAMAPKAPK5PTK6FLT3 | |
| SCHEMBL10169418 | 0.66 | MAPKAPK5 (0.51) | AURKBAURKAMAPKAPK5PTK6FLT3 | |
| SCHEMBL2402248 | 0.66 | MAPKAPK5 (0.51) | AURKBAURKAMAPKAPK5PTK6FLT3 | |
| SCHEMBL12473154 | 0.66 | AURKB (0.74) | AURKBAURKAPTK6LCKCHEK1 | |
| SCHEMBL13954946 | 0.66 | PTK6 (0.53) | AURKBAURKAMAPKAPK5PTK6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017701-A2 | ANTI-MITOTIC AGENT AND AURORA KINASE INHIBITOR COMBINATION AS ANTI-CANCER TREATMENT | SCHERING CORPORATION (US) | 2009-02-05 | — | — | WO | disclosed |