SCHEMBL1395504

SCHEMBL1395504

O=[N+]([O-])c1nccnc1-c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.49
MEN1 O00255 3/20 0.48
MAPT P10636 2/20 0.44
HPGD P15428 1/20 0.44
ABCC1 P33527 2/20 0.44
ABCB1 P08183 1/20 0.44
ALDH1A1 P00352 3/20 0.41
TDP1 Q9NUW8 1/20 0.41
ABCC8 Q09428 1/20 0.41
KCNJ11 Q14654 1/20 0.41
LMNA P02545 1/20 0.40
IDO1 P14902 1/20 0.39
OPRK1 P41145 1/20 0.39
PKM P14618 1/20 0.39
MAPK1 P28482 1/20 0.39
HTT P42858 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18447787 0.79 KMT2A (0.55) KMT2AMEN1MAPTHPGDALDH1A1
SCHEMBL444703 0.76 ALDH1A1 (0.53) KMT2AMEN1MAPTALDH1A1TDP1
SCHEMBL17404666 0.76 KMT2A (0.54) KMT2AMEN1MAPTABCC1ALDH1A1
SCHEMBL28133446 0.74 KMT2A (0.47) KMT2AMEN1MAPTHPGDABCC1
SCHEMBL3722614 0.73 KDM4E (0.41) KMT2AMEN1MAPTHPGDALDH1A1
SCHEMBL460510 0.73 ALOX15 (0.50) KMT2AMEN1MAPTHPGDALDH1A1
SCHEMBL27664892 0.73 ALOX15 (0.50) KMT2AMEN1MAPTHPGDALDH1A1
SCHEMBL8077700 0.72 CA12 (0.64) KMT2AMEN1MAPTHPGDABCC1
SCHEMBL10415950 0.72 ABCC8 (0.47) KMT2AMEN1MAPTHPGDABCC1
SCHEMBL8662385 0.72 ABCC8 (0.43) KMT2AMEN1MAPTHPGDABCC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4832697-A Hair dye preparations containing substantive nitrodiphenylamine derivatives HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1989-05-23 US claimed
CN-114206301-A Process for colouring keratin materials comprising the use of an organosilicon compound, a colouring effect pigment and a film-forming polymer II 汉高股份有限及两合公司 2022-03-18 CN disclosed
CN-114173754-A Process for colouring keratin materials comprising the use of an organosilicon compound, a colouring effect pigment and a film-forming polymer IV 汉高股份有限及两合公司 2022-03-11 CN disclosed
CN-114025739-A Process for dyeing keratin materials 汉高股份有限及两合公司 2022-02-08 CN disclosed
CN-113993504-A Agent for colouring keratin materials comprising an aminopolysiloxane, a colouring compound, a preservative and an ethoxylated fatty alcohol 汉高股份有限及两合公司 2022-01-28 CN disclosed
CN-113613623-A Containing two organic species C1-C6Agent for treating keratin fibres, comprising the reaction product of an alkoxysilane with water 汉高股份有限及两合公司 2021-11-05 CN disclosed
CN-113613622-A Preparation and use of compositions containing organic C1-C6Process for preparing hair treatment agent of alkoxysilane 汉高股份有限及两合公司 2021-11-05 CN disclosed
CN-113597299-A Preparation and use of compositions containing organic C1-C6Process for preparing hair treatment agent of alkoxysilane 汉高股份有限及两合公司 2021-11-02 CN disclosed
CN-113507919-A Preparation and use of compositions containing organic C1-C6Process for preparing hair treatment agent of alkoxysilane 汉高股份有限及两合公司 2021-10-15 CN disclosed
CN-113507918-A Process for preparing hair treatment agents containing organic C1-C6 alkoxysilanes 汉高股份有限及两合公司 2021-10-15 CN disclosed
US-8246697-B2 Mixture of amides and cosmetic compositions comprising said mixture KAO CORPORATION S.A. (ES) 2012-08-21 US disclosed
US-20120005843-A1 MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE Kao Corporation S.A, (ES) 2012-01-12 US disclosed
EP-2370398-A1 MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE KAO CORPORATION, S.A. (ES) 2011-10-05 EP disclosed
EP-1714677-B1 Long chain fatty acid dimethylaminopropylamide as levelling agent for dyeing kerationous fibres KAO CORP SA (ES) 2010-07-14 EP disclosed
WO-2010072810-A1 MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE KAO CORPORATION, S.A. (ES) 2010-07-01 WO disclosed
EP-2202219-A1 Mixture of amides and cosmetic compositions comprising said mixture KAO CORPORATION, S.A. (ES) 2010-06-30 EP disclosed
EP-1714677-A1 Long chain fatty acid dimethylaminopropylamide as levelling agent for dyeing kerationous fibres, or as thickening agent KAO CORPORATION, S.A. (ES) 2006-10-25 EP disclosed
EP-0994691-B1 USE OF ESTER QUATERNARIES AS EMULSIFIERS IN PREPARATIONS FOR COLORING KERATIN FIBERS COGNIS DEUTSCHLAND GMBH (DE) 2002-07-24 EP disclosed
EP-0994691-A1 USE OF ESTER QUATERNARIES AS EMULSIFIERS FOR PRODUCING PREPARATIONS FOR COLORING KERATIN FIBERS Cognis Deutschland GmbH (DE) 2000-04-26 EP disclosed
WO-1999011227-A1 USE OF ESTER QUATERNARIES AS EMULSIFIERS FOR PRODUCING PREPARATIONS FOR COLORING KERATIN FIBERS COGNIS DEUTSCHLAND GMBH (DE) 1999-03-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120005843-A1 MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE H1-0, H1-3, H1-4 KMT2A 1566/4885MEN1 1878/4885MAPT 3517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.