Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | AKT2 | P31751 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 5/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13132498 | 0.87 | CALCA (0.40) | MC4REPHX2 | |
| SCHEMBL14435264 | 0.80 | ADAM17 (0.40) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435253 | 0.80 | ADAM17 (0.40) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435596 | 0.74 | AKT1 (0.43) | AKT1DPP4 | |
| SCHEMBL12211500 | 0.74 | MC4R (0.43) | MC4REPHX2 | |
| SCHEMBL13132706 | 0.74 | MC4R (0.42) | MC4REPHX2 | |
| SCHEMBL13959559 | 0.74 | HDAC8 (0.42) | AKT1AKT2AKT3HDAC8HDAC1 | |
| SCHEMBL13132495 | 0.74 | CALCA (0.40) | MC4REPHX2 | |
| SCHEMBL12211426 | 0.73 | HDAC8 (0.42) | AKT1AKT2AKT3HDAC8HDAC1 | |
| SCHEMBL13960290 | 0.73 | HDAC8 (0.41) | AKT1AKT2AKT3HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010299-A1 | SUBSTITUTED HETEROARYLPIPERIDINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2009-01-22 | — | — | WO | disclosed |