Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12211426 | 0.94 | HDAC8 (0.42) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12210548 | 0.88 | CALCA (0.44) | MC4REPHX2 | |
| SCHEMBL12211443 | 0.87 | HDAC8 (0.41) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13959559 | 0.83 | HDAC8 (0.42) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14435273 | 0.83 | ADAM17 (0.39) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13132455 | 0.82 | CALCA (0.44) | MC4REPHX2 | |
| SCHEMBL14436417 | 0.82 | HDAC8 (0.47) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12713306 | 0.76 | HDAC8 (0.48) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL12210714 | 0.76 | GPR119 (0.49) | — | |
| SCHEMBL13132447 | 0.75 | CALCA (0.46) | MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2019100-A1 | Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators | Santhera Pharmaceuticals (Schweiz) AG (CH) | 2009-01-28 | — | — | EP | disclosed |