Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 5/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961816 | 0.85 | FPR1 (0.41) | FPR1HSD11B1MAPK14MAPK11ROCK2 | |
| SCHEMBL13962516 | 0.84 | FPR1 (0.41) | FPR1HSD11B1MAPK14ROCK2 | |
| SCHEMBL13961813 | 0.84 | FPR1 (0.40) | FPR1HSD11B1MAPK14MAPK11ROCK2 | |
| SCHEMBL3074521 | 0.83 | CNR2 (0.49) | HPGD | |
| SCHEMBL3074515 | 0.83 | HSD11B1 (0.58) | FPR1HSD11B1HPGD | |
| SCHEMBL13962522 | 0.81 | FPR1 (0.47) | FPR1HSD11B1ROCK2HPGD | |
| SCHEMBL13962474 | 0.81 | ALDH1A1 (0.45) | FPR1HSD11B1HPGD | |
| SCHEMBL13962771 | 0.81 | FPR1 (0.50) | FPR1HSD11B1KMT2AHPGD | |
| SCHEMBL13961805 | 0.80 | HSD11B1 (0.41) | FPR1HSD11B1ROCK2 | |
| SCHEMBL13962472 | 0.79 | HSD11B1 (0.38) | FPR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009010416-A2 | INHIBITORS OF 11B-HYDROXYSTEROID DEHYDROGENASE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-22 | — | — | WO | disclosed |