Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | PRKACG | P22612 | 1/20 | 0.33 |
| ▸ | PRKACB | P22694 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91360 | 0.85 | REN (0.44) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL1050732 | 0.83 | REN (0.42) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL13962817 | 0.83 | REN (0.42) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL4602445 | 0.83 | ICMT (0.44) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL13131404 | 0.82 | REN (0.41) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL78487 | 0.81 | REN (0.52) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL2805392 | 0.81 | REN (0.43) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL2811635 | 0.80 | PTGER4 (0.45) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL90184 | 0.79 | CNR2 (0.56) | CNR1CNR2ALDH1A1PRKACAPRKACG | |
| SCHEMBL2935768 | 0.79 | SLC22A12 (0.58) | RENCNR1CNR2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1717226-B1 | 2,7-SUBSTITUTED 5-AMINO-4-HYDROXY-8-(1H-INDOL-5-YL)-OCTAN AMIDE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | SPEEDEL EXPERIMENTA AG (CH) | 2009-01-21 | — | — | EP | disclosed |