Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.34 |
| ▸ | S100A10 | P60903 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91360 | 0.83 | REN (0.44) | RENALDH1A1LMNAL3MBTL1CNR1 | |
| SCHEMBL16471683 | 0.82 | REN (0.51) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL78478 | 0.82 | REN (0.41) | RENBRD4L3MBTL1CNR1CNR2 | |
| SCHEMBL13962817 | 0.81 | REN (0.42) | RENALDH1A1CNR1CNR2PDE4A | |
| SCHEMBL13962829 | 0.81 | REN (0.42) | RENALDH1A1CNR1CNR2PDE4A | |
| SCHEMBL1050732 | 0.81 | REN (0.42) | RENALDH1A1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL4602445 | 0.81 | ICMT (0.44) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL13131404 | 0.80 | REN (0.41) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL2805392 | 0.78 | REN (0.43) | RENCNR1CNR2PDE4APDE4B | |
| SCHEMBL2811635 | 0.77 | PTGER4 (0.45) | RENALDH1A1LMNACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |