Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 9/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.51 |
| ▸ | AHCY | P23526 | 5/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923467 | 0.88 | AHCY (0.60) | ADORA2BADORA2AAHCYHIF1ATMEM97 | |
| SCHEMBL13964659 | 0.88 | AHCY (0.60) | ADORA2BADORA2AAHCYHIF1ATMEM97 | |
| SCHEMBL12300947 | 0.87 | AHCY (0.68) | ADORA2BADORA2AAHCYHIF1ATMEM97 | |
| SCHEMBL26554199 | 0.87 | AHCY (0.68) | ADORA2BADORA2AAHCYHIF1ATMEM97 | |
| SCHEMBL13382546 | 0.82 | AHCY (0.74) | ADORA2BADORA2AAHCYHIF1ATMEM97 | |
| SCHEMBL18253324 | 0.80 | SMN1; SMN2 (0.52) | ADORA2BADORA2AADORA3ADORA1KMT2A | |
| SCHEMBL13964754 | 0.80 | ADORA2A (0.52) | ADORA2BADORA2AADORA3 | |
| SCHEMBL12151645 | 0.79 | SMN1; SMN2 (0.42) | ADORA2BADORA2AADORA3ADORA1KMT2A | |
| SCHEMBL13530847 | 0.79 | SMN1; SMN2 (0.42) | ADORA2BADORA2AADORA3ADORA1KMT2A | |
| SCHEMBL13400312 | 0.77 | PI4KA (0.53) | ADORA2BADORA2AAHCYHIF1ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180079773-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | GILEAD SCIENCES, INC. | 2018-03-22 | — | — | US | disclosed |
| US-9783567-B2 | Processes and intermediates for preparing anti-HIV agents | GILEAD SCIENCES, INC. (US) | 2017-10-10 | — | — | US | disclosed |
| US-20160340379-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | GILEAD SCIENCES, INC. | 2016-11-24 | — | — | US | disclosed |
| US-9296779-B2 | Processes and intermediates for preparing anti-HIV agents | GILEAD SCIENCES, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150203525-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | GILEAD SCIENCES, INC. | 2015-07-23 | — | — | US | disclosed |
| US-8987437-B2 | Processes and intermediates for preparing anti-HIV Agents | GILEAD SCIENCES, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20120296076-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | GILEAD SCIENCES, INC. | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296076-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | SAMHD1, DHPS, LSS | ADORA2B 4029/4885ADORA2A 3746/4885AHCY 2754/4885 |
| US-20150203525-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | SAMHD1, DHPS, LSS | ADORA2B 4029/4885ADORA2A 3746/4885AHCY 2754/4885 |
| US-20160340379-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | SAMHD1, DHPS, LSS | ADORA2B 4029/4885ADORA2A 3746/4885AHCY 2754/4885 |
| US-20180079773-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-HIV AGENTS | SAMHD1, DHPS, LSS | ADORA2B 4029/4885ADORA2A 3746/4885AHCY 2754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.