Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | MST1R | Q04912 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.47 |
| ▸ | HGF | P14210 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396699 | 0.84 | MET (0.57) | METKDRMST1RAXL | |
| SCHEMBL19689606 | 0.81 | MET (0.55) | METKDRMST1RHGFSRC | |
| SCHEMBL3855044 | 0.79 | MET (0.55) | METKDRMST1RHGF | |
| SCHEMBL3912894 | 0.79 | MET (0.60) | METKDRMST1RAXL | |
| SCHEMBL4774400 | 0.78 | AXL (0.51) | METKDRMST1RAXLSRC | |
| SCHEMBL1396822 | 0.77 | MET (0.49) | METKDRAXLSRCTGFBR1 | |
| SCHEMBL1396842 | 0.75 | PTK2B (0.52) | METKDR | |
| SCHEMBL5304436 | 0.75 | MET (0.52) | METKDRMST1RAXLSRC | |
| SCHEMBL19689580 | 0.75 | MET (0.55) | METKDRMST1RHGF | |
| SCHEMBL1396738 | 0.75 | MET (0.48) | METKDRSRCTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288383-A1 | COMBINATIONS VEGF(R) INHIBITORS AND HEPATOCYTE GROWTH FACTOR (C-MET) INHIBITORS FOR THE TREATMENT OF CANCER | Amgen, Inc (US) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009140549-A1 | COMBINATIONS VEGF(R) INHIBITORS AND HEPATOCYTE GROWTH FACTOR (C-MET) INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2009-11-19 | — | — | WO | disclosed |
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |