Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.51 |
| ▸ | MET | P08581 | 14/20 | 0.47 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | MST1R | Q04912 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1396734 | 0.93 | AXL (0.49) | AXLMETSRCTGFBR1KDR | |
| SCHEMBL5186596 | 0.83 | MET (0.53) | AXLMETSRCTGFBR1KDR | |
| SCHEMBL1396676 | 0.81 | KDR (0.46) | AXLMETSRCKDRPDGFRA | |
| SCHEMBL5304436 | 0.80 | MET (0.52) | AXLMETSRCTGFBR1KDR | |
| SCHEMBL2325654 | 0.79 | MET (0.52) | METSRCTGFBR1KDRPDGFRA | |
| SCHEMBL5305342 | 0.78 | MET (0.48) | AXLMETSRCTGFBR1KDR | |
| SCHEMBL1396733 | 0.78 | MET (0.51) | AXLMETSRCTGFBR1KDR | |
| SCHEMBL5056214 | 0.76 | MET (0.52) | METKDR | |
| SCHEMBL5307620 | 0.75 | MET (0.53) | AXLMETKDR | |
| SCHEMBL3911419 | 0.73 | MET (0.60) | AXLMETSRCKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |