Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534800 | 0.85 | SMN1; SMN2 (0.62) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL2526216 | 0.85 | ALDH1A1 (0.64) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12233149 | 0.82 | POLB (0.53) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4494006 | 0.79 | ALDH1A1 (0.82) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4485648 | 0.78 | POLB (1.00) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12092840 | 0.77 | ITGB3 (0.56) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12284107 | 0.77 | PKM (0.59) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL12210642 | 0.76 | PKM (0.61) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL16270108 | 0.75 | GRM5 (0.64) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL18361787 | 0.74 | POLB (0.51) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255103-B2 | Substituted pyrazolo[1,5-a]pyrazines as mGluR5 receptor modulators | VANDERBILT UNIVERSITY (US) | 2016-02-09 | — | — | US | disclosed |
| US-20140213593-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY | 2014-07-31 | — | — | US | disclosed |
| US-8703946-B2 | Substituted pyrazolo[1,5-A]pyrazine compounds as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2014-04-22 | — | — | US | disclosed |
| US-20120295913-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213593-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | POLB 4591/4885SMN1; SMN2 2961/4885ALDH1A1 4491/4885 |
| US-20120295913-A1 | BICYCLIC PYRAZOLE COMPOUNDS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | POLB 4591/4885SMN1; SMN2 2961/4885ALDH1A1 4491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.