Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CENPE | Q02224 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397826 | 0.93 | C5AR1 (0.35) | TRPM8CENPEMAPTTP53C5AR1 | |
| SCHEMBL1397409 | 0.89 | C5AR1 (0.38) | CENPEC5AR1MEN1KMT2ACYP2C19 | |
| SCHEMBL1397663 | 0.87 | C5AR1 (0.34) | MAPTTP53C5AR1MEN1KMT2A | |
| SCHEMBL1397655 | 0.84 | MAPT (0.35) | TRPM8KDM4EMAPTTP53MEN1 | |
| SCHEMBL1397686 | 0.82 | TP53 (0.35) | KDM4EMAPTTP53MEN1KMT2A | |
| SCHEMBL1397672 | 0.79 | EEF2K (0.30) | NR1I3 | |
| SCHEMBL1397699 | 0.78 | C5AR1 (0.31) | C5AR1NR1I3 | |
| SCHEMBL1397533 | 0.78 | TP53 (0.31) | MAPTTP53NR1I3 | |
| SCHEMBL1397674 | 0.78 | LMNA (0.33) | MAPTMEN1KMT2AALDH1A1NR1I3 | |
| SCHEMBL1397538 | 0.78 | THRB (0.32) | MAPTTP53SIGMAR1IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |