Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438354 | 0.81 | CYP1A2 (0.47) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL11832284 | 0.80 | CYP1A2 (0.51) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL9702126 | 0.79 | SMN1; SMN2 (0.57) | SLC6A3KDM4EKCNA5TSHRADRA2A | |
| SCHEMBL5052299 | 0.77 | ALDH1A1 (0.55) | SLC6A3SLC6A2SLC6A4KDM4ETSHR | |
| SCHEMBL11822524 | 0.77 | CYP1A2 (0.41) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL11820590 | 0.76 | KCNA5 (0.44) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL11815244 | 0.76 | TSHR (0.46) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL11712140 | 0.76 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL11036187 | 0.75 | CYP3A4 (0.46) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 | |
| SCHEMBL10717053 | 0.75 | SLC6A2 (0.41) | SLC6A3SLC6A2SLC6A4KDM4EKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5319674-B2 | — | — | 2013-10-16 | — | — | JP | disclosed |
| US-8410157-B2 | Fungicidal N-cycloalkyl-benzyl-thiocarboxamides or N-cycloalkyl-benzyl-N′-substituted-amidine derivatives | BAYER CROPSCIENCE AG (DE) | 2013-04-02 | — | — | US | disclosed |
| US-8309592-B2 | — | — | 2012-11-13 | — | — | US | disclosed |
| CN-101772495-B | Fungicide 2-pyridyl-methylene-thio carboxamide or 2-pyridyl-methylene-N-substituted carboximidamide derivatives | BAYER CROPSCIENCE SA | 2012-08-29 | — | — | CN | disclosed |
| EP-2182800-B1 | FUNGICIDAL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N' -SUBSTITUTED-AMIDINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2011-03-02 | — | — | EP | disclosed |
| CN-101772495-A | fungicide 2-pyridyl-methylene-thio carboxamide or 2-pyridyl-methylene-n-substituted carboximidamide derivatives | BAYER CROPSCIENCE SA | 2010-07-07 | — | — | CN | disclosed |
| US-20100144817-A1 | FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES | BAYER SAS (FR) | 2010-06-10 | — | — | US | disclosed |
| US-20100130560-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | BAYER SAS (FR) | 2010-05-27 | — | — | US | disclosed |
| US-20100130560-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | BAYER SAS (FR) | 2010-05-27 | — | — | US | disclosed |
| EP-2185548-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | Bayer CropScience SA (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-2185548-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | Bayer CropScience SA (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-2182800-A1 | FUNGICIDAL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N' -SUBSTITUTED-AMIDINE DERIVATIVES | Bayer CropScience SA (FR) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009016220-A1 | FUNGICIDAL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N' -SUBSTITUTED-AMIDINE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016219-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009016219-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | BAYER CROPSCIENCE SA (FR) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144817-A1 | FUNGICIDEL N-CYCLOALKYL-BENZYL-THIOCARBOXAMIDES OR N-CYCLOALKYL-BENZYL-N'-SUBSTITUTED-AMIDINE DERIVATIVES | CBR3, NRDC, NAT1 | SLC6A3 3294/4885SLC6A2 4202/4885SLC6A4 2979/4885 |
| US-20100130560-A1 | FUNGICIDE 2-PYRIDYL-METHYLENE-THIO CARBOXAMIDE OR 2-PYRIDYL-METHYLENE-N-SUBSTITUTED CARBOXIMIDAMIDE DERIVATIVES | CBR3, CBR1, CNPY2 | SLC6A3 4038/4885SLC6A2 4505/4885SLC6A4 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.