Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14051498 | 0.82 | AOC3 (0.47) | AOC3HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL2056286 | 0.79 | PDE4B (0.50) | AOC3HDAC1HDAC8HDAC6PDE4B | |
| SCHEMBL8836113 | 0.79 | HDAC1 (0.53) | AOC3HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL31375555 | 0.78 | CES1 (0.34) | AOC3HDAC1HDAC8HDAC6DRD2 | |
| SCHEMBL28331877 | 0.77 | HSD11B1 (0.47) | KMT2A | |
| SCHEMBL3085910 | 0.76 | PDE4B (0.51) | AOC3HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL5540418 | 0.76 | PDE4B (0.50) | AOC3HDAC1HDAC8HDAC6PDE4B | |
| SCHEMBL5310580 | 0.76 | ACHE (0.56) | AOC3HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL6639205 | 0.76 | HDAC1 (0.51) | AOC3HDAC1HDAC8HDAC6ENPP3 | |
| SCHEMBL3951956 | 0.75 | ENPP3 (0.53) | AOC3HDAC1HDAC8HDAC6ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023707-A1 | AMINOALKYLAZOLE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | HRH4, HRH3, HRH2 | AOC3 135/4885HDAC1 1951/4885HDAC8 2412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.