Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 5/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 4/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13966328 | 1.00 | LIPE (0.55) | LIPECHRM4BCHEACHEBACE1 | |
| SCHEMBL13835453 | 1.00 | LIPE (0.55) | LIPECHRM4BCHEACHEBACE1 | |
| SCHEMBL13836141 | 0.84 | LIPE (0.68) | LIPEBCHEACHEBACE1 | |
| SCHEMBL13966330 | 0.84 | LIPE (0.68) | LIPEBCHEACHEBACE1 | |
| SCHEMBL13975599 | 0.84 | LIPE (0.68) | LIPEBCHEACHEBACE1 | |
| SCHEMBL23701396 | 0.84 | KMT2A (0.55) | ACHEDRD2DRD3 | |
| SCHEMBL9042636 | 0.83 | SMN1; SMN2 (0.52) | ACHEDRD2DRD4DRD3 | |
| SCHEMBL1749014 | 0.83 | SMN1; SMN2 (0.52) | ACHEDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL1749238 | 0.81 | SMN1; SMN2 (0.51) | ACHEDRD2DRD4DRD3 | |
| SCHEMBL13835992 | 0.81 | LIPE (0.83) | LIPEBCHEACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295934-A1 | New Hexahydrocyclopentapyrrolone, Hexahydropyrrolopyrrolone, Octahydropyrrolopyridinone and Octahydropyridinone Compounds | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120295934-A1 | New Hexahydrocyclopentapyrrolone, Hexahydropyrrolopyrrolone, Octahydropyrrolopyridinone and Octahydropyridinone Compounds | LIPE, LIPC, PNLIP | LIPE 1/4885CHRM4 2086/4885BCHE 1787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.