Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.69 |
| ▸ | PPARG | P37231 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.69 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | MAOB | P27338 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17383074 | 0.79 | HPGD (0.75) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL13401576 | 0.78 | MAPK1 (0.65) | SMN1; SMN2MAPTKMT2ANPSR1RXFP1 | |
| SCHEMBL3365328 | 0.78 | MEN1 (0.64) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL7421481 | 0.78 | CTSB (0.50) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL2949736 | 0.78 | RAB9A (1.00) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL31325504 | 0.78 | RAB9A (1.00) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL1132916 | 0.76 | ALDH1A1 (0.44) | SMN1; SMN2MEN1KMT2APPARGRXFP1 | |
| SCHEMBL9178002 | 0.73 | GAA (0.60) | MAPTKMT2APKMTSHRHPGD | |
| SCHEMBL6866813 | 0.72 | SCN9A (0.52) | SMN1; SMN2MAPTRAB9ANPC1MAOB | |
| SCHEMBL15693653 | 0.71 | NPC1 (0.69) | SMN1; SMN2MAPTMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221840-B2 | Treating protein folding disorders with small molecule CFTR correctors | DISCOVERYBIOMED INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9221840-B2 | Treating protein folding disorders with small molecule CFTR correctors | DISCOVERYBIOMED INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | THE UAB RESEARCH FOUNDATION (US) | 2014-03-13 | — | — | US | disclosed |
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | THE UAB RESEARCH FOUNDATION (US) | 2014-03-13 | — | — | US | disclosed |
| WO-2012158913-A2 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | DISCOVERYBIOMED INC. (US) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073632-A1 | TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS | CFTR, CLCN2, SLC47A1 | SMN1; SMN2 1902/4885MAPT 4188/4885MEN1 4193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.