Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136645 | 0.83 | SLC6A4 (0.43) | SLC6A4SLC6A2MEN1CYP2D6KMT2A | |
| SCHEMBL5774531 | 0.80 | MKNK1 (0.35) | SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL4577662 | 0.75 | SLC6A4 (0.46) | SLC6A4SLC6A2MEN1CYP2D6KMT2A | |
| SCHEMBL4617051 | 0.75 | HTR2C (0.45) | SLC6A4SLC6A2GABRA1GABRB2SLC6A3 | |
| SCHEMBL16503429 | 0.71 | SLC6A2 (0.57) | SLC6A4SLC6A2MEN1CYP2D6KMT2A | |
| SCHEMBL24230522 | 0.69 | DDB1 (0.36) | HTR2CALDH1A1 | |
| SCHEMBL7295719 | 0.69 | KIF11 (0.41) | ALDH1A1 | |
| SCHEMBL3245656 | 0.69 | HTT (0.36) | SLC6A4SLC6A2MEN1KMT2ATRPM8 | |
| SCHEMBL2323552 | 0.68 | SLC6A4 (0.38) | SLC6A4SLC6A2MEN1CYP2D6KMT2A | |
| SCHEMBL14855593 | 0.67 | TRPM8 (0.41) | MEN1KMT2ATRPM8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1396487-B1 | PHENYLPYRIDINE CARBONYL PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2008-12-10 | — | — | EP | disclosed |