Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADH1A | P07327 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADH1C | P00326 | 1/20 | 0.33 |
| ▸ | ADH4 | P08319 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14855593 | 0.94 | TRPM8 (0.41) | HTTTRPM8ALDH1A1MEN1KMT2A | |
| SCHEMBL14855772 | 0.92 | TRPM8 (0.44) | TRPM8ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL14855822 | 0.90 | TRPM8 (0.46) | TRPM8ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3245978 | 0.90 | TRPM8 (0.46) | TRPM8ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4136645 | 0.87 | SLC6A4 (0.43) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28213143 | 0.84 | LTA4H (0.40) | HTTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL15284332 | 0.84 | HTR2A (0.49) | ALDH1A1MEN1KMT2AKDM4ESLC6A2 | |
| SCHEMBL28304677 | 0.82 | GAA (0.34) | HTTTRPM8ALDH1A1NPSR1ALOX15 | |
| SCHEMBL24230522 | 0.79 | DDB1 (0.36) | HTTALDH1A1SMN1; SMN2ADH1AADH1C | |
| SCHEMBL28288420 | 0.79 | ADH1A (0.31) | ADH1AADH1CADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368494-A | Methods, compositions and uses of novel FYN kinase inhibitors | 沃伦·C·刘 | 2018-08-03 | — | — | CN | claimed |
| CN-107848974-A | Aromatic sulfonamide derivatives | 拜耳制药股份公司 | 2018-03-27 | — | — | CN | claimed |
| CN-105431436-B | Pyrrolo [2,3-D ] pyrimidine derivatives, processes for their preparation and their use as kinase inhibitors | 内尔维阿诺医学科学有限公司 | 2017-11-28 | — | — | CN | claimed |
| CN-110167926-A | POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS | 米托布里奇公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-110023312-A | The Compounds and methods for for preventing malarial parasite from propagating | 由卫生与公众服务部部长代表的美利坚合众国 | 2019-07-16 | — | — | CN | disclosed |
| CN-106103414-B | Substituted benzamides for arthropod processing | 拜耳作物科学股份公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-109734677-A | The small molecule compound and its application of inhibition of histone lysine methyltransferase NSD2 | 四川大学 | 2019-05-10 | — | — | CN | disclosed |
| CN-108617166-A | Protein Kinase Inhibitor Benzolactam Compounds | 大冢制药株式会社 | 2018-10-02 | — | — | CN | disclosed |
| CN-108383836-A | Heterocyclyl compounds as mek inhibitor | 鲁宾有限公司 | 2018-08-10 | — | — | CN | disclosed |
| CN-108264506-A | Novel isoflavone derivative, preparation method and medical usage | 中国药科大学 | 2018-07-10 | — | — | CN | disclosed |
| CN-107848974-A | Aromatic sulfonamide derivatives | 拜耳制药股份公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107033069-A | A kind of novel cloth Shandong tyrosine kinase irreversible inhibitor | 中国科学院合肥物质科学研究院 | 2017-08-11 | — | — | CN | disclosed |
| CN-106795119-A | Halogenated compound | 拜耳动物保健有限责任公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-104059343-B | A kind of polylactic acid composition and moulded products thereof, preparation method, and application thereof | 中国科学院化学研究所 | 2016-08-31 | — | — | CN | disclosed |
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | HORIKOSHI, HIROYOSHI (CA) | 2013-06-27 | — | — | US | disclosed |
| EP-2581373-A1 | BENZO- OR PYRIDO-IMIDAZOLE DERIVATIVE | Fujita, Takashi (JP) | 2013-04-17 | — | — | EP | disclosed |
| EP-1167366-B1 | AMINE DERIVATIVES | DAIICHI SANKYO CO LTD (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-6562849-B1 | Amine compound or pharmacologically acceptable salt thereof. These compounds are useful in the treatment and/or prophylaxis of diseases such as diabetes, hyperlipemia, arteriosclerosis, cancer, etc. | SANKYO COMPANY, LIMITED (JP) | 2003-05-13 | — | — | US | disclosed |
| US-20030078426-A1 | Amine derivative compounds | SANKYO COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| EP-1167366-A1 | AMINE DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078426-A1 | Amine derivative compounds | H1-10, APOB, PRMT1 | HTT 3024/4885TRPM8 2933/4885ALDH1A1 874/4885 |
| US-20130165446-A1 | BENZO-OR PYRIDO-IMIDAZOLE DERIVATIVE | PPARG, PPARA, PPARD | HTT 4759/4885TRPM8 845/4885ALDH1A1 1612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.