Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14884740 | 0.86 | STAT3 (1.00) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL10203639 | 0.85 | STAT3 (0.72) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL10165364 | 0.85 | STAT3 (0.72) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL1521245 | 0.85 | STAT3 (0.76) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL26694396 | 0.84 | POLB (0.71) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL16234643 | 0.81 | STAT3 (0.50) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL2187853 | 0.79 | STAT3 (0.67) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL7292220 | 0.79 | ALDH1A1 (0.66) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL8530610 | 0.78 | KMT2A (0.69) | STAT3POLBMAPTALDH1A1KMT2A | |
| SCHEMBL8530608 | 0.76 | KMT2A (0.48) | STAT3POLBMAPTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8883766-B2 | Ion channel modulators and methods of use | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-11-11 | — | — | US | disclosed |
| WO-2008147797-A2 | ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-04 | — | — | WO | disclosed |