Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.55 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PLEC | Q15149 | 1/20 | 0.43 |
| ▸ | PPM1D | O15297 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981968 | 0.86 | LOXL2 (0.48) | HIF1AALDH1A1HPGDKDM4EGAA | |
| SCHEMBL6266178 | 0.82 | KDM5A (0.56) | MRGPRX4KDM5AALDH1A1HPGDKDM4E | |
| SCHEMBL30535169 | 0.76 | GAA (0.65) | MRGPRX4ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL7993941 | 0.76 | GAA (0.65) | MRGPRX4ALDH1A1HPGDKDM4EGAA | |
| SCHEMBL14420823 | 0.73 | MRGPRX4 (0.59) | MRGPRX4HIF1AALDH1A1HPGDPPM1D | |
| SCHEMBL12775045 | 0.71 | FOLH1 (0.58) | HIF1AKMT2AMEP1B | |
| SCHEMBL22469681 | 0.71 | MRGPRX4 (1.00) | MRGPRX4HIF1APPM1DL3MBTL1POLB | |
| SCHEMBL31568452 | 0.71 | MRGPRX4 (1.00) | MRGPRX4HIF1APPM1DL3MBTL1POLB | |
| SCHEMBL1231292 | 0.71 | CYP1A2 (0.65) | ALDH1A1HPGDKDM4EMAPTAURKA | |
| SCHEMBL4497861 | 0.70 | MRGPRX4 (0.75) | MRGPRX4HIF1AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |