Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.75 |
| ▸ | PPM1D | O15297 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22469681 | 0.86 | MRGPRX4 (1.00) | MRGPRX4PPM1DHIF1AMEN1KMT2A | |
| SCHEMBL31568452 | 0.86 | MRGPRX4 (1.00) | MRGPRX4PPM1DHIF1AMEN1KMT2A | |
| SCHEMBL14420823 | 0.82 | MRGPRX4 (0.59) | MRGPRX4PPM1DHIF1AHPGDHDAC8 | |
| SCHEMBL14420722 | 0.82 | PPM1D (0.60) | MRGPRX4PPM1DHIF1AHPGDHDAC8 | |
| SCHEMBL4509041 | 0.81 | SENP1 (0.53) | MRGPRX4HIF1ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22480951 | 0.80 | MRGPRX4 (0.71) | MRGPRX4 | |
| SCHEMBL1287947 | 0.80 | HIF1A (0.83) | MRGPRX4HIF1ANPC1RAB9AKMT2A | |
| SCHEMBL2316630 | 0.79 | HSD17B10 (0.59) | MEN1KMT2AHPGDHDAC8HDAC6 | |
| SCHEMBL1841502 | 0.78 | MAPT (0.56) | MRGPRX4PPM1DHIF1ARAB9AMEN1 | |
| SCHEMBL11511610 | 0.78 | MRGPRX4 (0.52) | MRGPRX4KMT2ALMNAHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837828-B | It is used as the phenylethyl pyridine derivate of PDE4 inhibitor | 奇斯药制品公司 | 2017-07-18 | — | — | CN | disclosed |
| CN-104837828-A | Phenylethylpyridine derivatives as PDE4-inhibitors | CHIESI FARMA SPA | 2015-08-12 | — | — | CN | disclosed |
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | MRGPRX4 1550/4885PPM1D 4471/4885HIF1A 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.