Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | PPM1D | O15297 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13981982 | 0.86 | MRGPRX4 (0.55) | PPM1DHIF1AHPGDGAAMAPT | |
| SCHEMBL8037982 | 0.77 | KDM4E (0.54) | LOXL2PPM1DCA1CA2HIF1A | |
| SCHEMBL31072837 | 0.77 | HDAC8 (0.57) | HIF1AHPGDGAAMAPTERAP2 | |
| SCHEMBL15687652 | 0.76 | CA1 (0.61) | LOXL2PPM1DCA1CA2HIF1A | |
| SCHEMBL14420824 | 0.75 | LOXL2 (0.58) | LOXL2PPM1DCA1CA2HIF1A | |
| SCHEMBL3566972 | 0.74 | LOXL2 (0.58) | LOXL2CA1CA2HIF1AHPGD | |
| SCHEMBL1180032 | 0.74 | LOXL2 (0.53) | LOXL2PPM1DHIF1ALMNAHPGD | |
| SCHEMBL31237125 | 0.74 | MRGPRX4 (0.57) | LOXL2PPM1DHIF1ACYP4F2CYP4A11 | |
| SCHEMBL23286785 | 0.74 | CA1 (0.61) | LOXL2CA1CA2HIF1AHPGD | |
| SCHEMBL22469948 | 0.73 | MRGPRX4 (0.74) | LOXL2PPM1DHIF1AHPGDCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148449-A1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2008-12-11 | — | — | WO | disclosed |