Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 14/20 | 0.71 |
| ▸ | MMP9 | P14780 | 9/20 | 0.71 |
| ▸ | MMP13 | P45452 | 4/20 | 0.56 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 2/20 | 0.56 |
| ▸ | MMP10 | P09238 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.53 |
| ▸ | MMP7 | P09237 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | CTSS | P25774 | 2/20 | 0.52 |
| ▸ | CTSK | P43235 | 2/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13266866 | 1.00 | MMP2 (0.71) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL3016012 | 0.92 | MMP2 (0.58) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL13244755 | 0.92 | MMP2 (0.58) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL3016017 | 0.92 | MMP2 (0.58) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL13267482 | 0.88 | ADAMTS4 (0.56) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL13267165 | 0.85 | ADAMTS4 (0.54) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL32691785 | 0.84 | MMP2 (1.00) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL2454204 | 0.84 | MMP2 (1.00) | MMP2MMP9MMP13MMP3MMP14 | |
| SCHEMBL13244938 | 0.81 | MMP2 (0.55) | MMP2MMP9MMP13MMP3ADAMTS4 | |
| SCHEMBL13244941 | 0.80 | ADAMTS4 (0.50) | MMP2MMP9MMP13MMP3ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |