Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244942 | 0.91 | MMP2 (0.51) | ADAMTS4MMP2MMP13MMP3 | |
| SCHEMBL13266866 | 0.85 | MMP2 (0.71) | ADAMTS4MMP2MMP13MMP1MMP3 | |
| SCHEMBL13984815 | 0.85 | MMP2 (0.71) | ADAMTS4MMP2MMP13MMP1MMP3 | |
| SCHEMBL13267164 | 0.83 | ADAMTS4 (0.62) | ADAMTS4MMP2MMP13MMP1MMP3 | |
| SCHEMBL13267482 | 0.81 | ADAMTS4 (0.56) | ADAMTS4MMP2MMP13MMP1MMP3 | |
| SCHEMBL13244755 | 0.77 | MMP2 (0.58) | ADAMTS4MMP2MMP13MMP3MMP9 | |
| SCHEMBL3016012 | 0.77 | MMP2 (0.58) | ADAMTS4MMP2MMP13MMP3MMP9 | |
| SCHEMBL3016017 | 0.77 | MMP2 (0.58) | ADAMTS4MMP2MMP13MMP3MMP9 | |
| SCHEMBL13244664 | 0.74 | ADAMTS4 (0.55) | ADAMTS4MMP13MMP1MMP9MMP14 | |
| SCHEMBL13266867 | 0.74 | MMP1 (0.61) | ADAMTS4MMP2MMP13MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | ADAMTS4 3184/4885MMP2 446/4885MMP13 2049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.