Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CALCRL | Q16602 | 4/20 | 0.49 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13985082 | 0.90 | SMN1; SMN2 (0.53) | SMN1; SMN2CALCRLALDH1A1KDM4EMAPT | |
| SCHEMBL13985249 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2CALCRLAKT1NPY1RKCNH2 | |
| SCHEMBL4756936 | 0.85 | CALCRL (0.53) | SMN1; SMN2CALCRLALDH1A1KDM4EMAPT | |
| SCHEMBL13985253 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2CALCRLALDH1A1KDM4EMAPT | |
| SCHEMBL13985283 | 0.77 | SMN1; SMN2 (0.57) | SMN1; SMN2CALCRLALDH1A1KDM4EMAPT | |
| SCHEMBL4755677 | 0.76 | CALCRL (0.54) | SMN1; SMN2CALCRLMAPTGAAPOLB | |
| SCHEMBL13985036 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL24987981 | 0.75 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL4757015 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL23500811 | 0.72 | SMN1; SMN2 (0.66) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |