Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755677 | 0.88 | CALCRL (0.54) | CALCRLGAASMN1; SMN2MAPTDGAT1 | |
| SCHEMBL13985180 | 0.85 | SMN1; SMN2 (0.53) | CALCRLGAAKDM4ESMN1; SMN2HPGD | |
| SCHEMBL4755125 | 0.84 | TP53 (0.45) | CALCRLKDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL4758257 | 0.82 | RXRA (0.43) | CALCRLNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL4758251 | 0.76 | CALCRL (0.46) | CALCRLNPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4757749 | 0.73 | CALCRL (0.38) | CALCRLSMN1; SMN2MAPTALDH1A1MEN1 | |
| Lithium SCHEMBL4757890 | 0.72 | NOTUM (0.48) | CALCRLSMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL4757886 | 0.72 | NOTUM (0.48) | CALCRLSMN1; SMN2MAPTALDH1A1TSHR | |
| SCHEMBL13985249 | 0.71 | SMN1; SMN2 (0.49) | CALCRLKDM4ESMN1; SMN2HPGDNPSR1 | |
| SCHEMBL4757784 | 0.70 | CALCRL (0.53) | CALCRLSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2009000819-A1 | 5-PHENYL-1,3,4-OXADIAZOL-2-YL-ACETYL-4-PIPERIDINYL DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | WO | disclosed |