Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.61 |
| ▸ | AR | P10275 | 3/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.61 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10910515 | 0.93 | PGR (0.67) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL10910516 | 0.93 | PGR (0.67) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL13653812 | 0.93 | PGR (0.62) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL13524488 | 0.93 | PGR (0.66) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL10903845 | 0.92 | PGR (0.58) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL13653820 | 0.92 | PGR (0.56) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL10944496 | 0.91 | PGR (0.67) | PGRCYP3A4ARF2HIF1A | |
| Methylprednisolone Aceponate SCHEMBL8612416 | 0.91 | PGR (0.74) | PGRCYP3A4ARF2HIF1A | |
| Methylprednisolone Aceponate SCHEMBL8961317 | 0.91 | PGR (0.74) | PGRCYP3A4ARF2HIF1A | |
| SCHEMBL10944492 | 0.91 | PGR (0.67) | PGRCYP3A4ARF2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470724-B2 | Phosphonate compounds having immuno-modulatory activity | GILEAD SCIENCES, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |