Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.62 |
| ▸ | AR | P10275 | 3/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.51 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900405 | 0.95 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10900414 | 0.95 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906137 | 0.94 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10906135 | 0.94 | NR3C1 (0.63) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10910516 | 0.94 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL10910515 | 0.94 | PGR (0.67) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL13524488 | 0.93 | PGR (0.66) | PGRCYP3A4ARF2NR3C1 | |
| SCHEMBL13985488 | 0.93 | PGR (0.61) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8612416 | 0.92 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 | |
| Methylprednisolone Aceponate SCHEMBL8961317 | 0.92 | PGR (0.74) | PGRCYP3A4ARF2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | CANNIZZARO CARINA | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227543-A1 | PHOSPHONATE COMPOUNDS HAVING IMMUNO-MODULATORY ACTIVITY | PHOSPHO1, NFATC1, IFNG | PGR 3296/4885CYP3A4 3919/4885AR 4355/4885 |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | PGR 1197/4885CYP3A4 1894/4885AR 3594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.