Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 7/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.39 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL209811 | 0.85 | KCNH2 (0.53) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL4755253 | 0.84 | LMNA (0.39) | LMNAALDH1A1MAPT | |
| SCHEMBL4755250 | 0.84 | LMNA (0.39) | LMNAALDH1A1MAPT | |
| SCHEMBL13985469 | 0.82 | MAPT (0.47) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL7660292 | 0.77 | ALDH1A1 (0.56) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL4467502 | 0.77 | ALDH1A1 (0.56) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL456801 | 0.75 | MAPT (0.55) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL17254431 | 0.75 | MAPT (0.53) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL6484230 | 0.74 | MAPT (0.58) | LMNAALDH1A1MAPTGPR119KCNH2 | |
| SCHEMBL1114019 | 0.73 | LMNA (0.63) | LMNAALDH1A1MAPTGPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001021-A1 | IMIDAZOPYRIDINE DERIVATIVES USEFUL AS ENZYME INHIBITORS FOR THE TREATMENT OF CELL PROLIFERATIVE AND AUTOIMMUNE DISEASES | CHROMA THERAPEUTICS LTD. (GB) | 2008-12-31 | — | — | WO | disclosed |