Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 3/20 | 1.00 |
| ▸ | PRMT1 | Q99873 | 6/20 | 0.90 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.90 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.90 |
| ▸ | WDR5 | P61964 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.85 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.85 |
| ▸ | DPY30 | Q9C005 | 1/20 | 0.85 |
| ▸ | ASH2L | Q9UBL3 | 1/20 | 0.85 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.84 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.84 |
| ▸ | TRDMT1 | O14717 | 5/20 | 0.79 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.77 |
| ▸ | RNMT | O43148 | 1/20 | 0.75 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13986348 | 1.00 | DOT1L (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL23120178 | 0.96 | WDR5 (0.93) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL15326840 | 0.91 | SMYD3 (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL13986347 | 0.91 | SMYD3 (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL14174647 | 0.91 | SMYD3 (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL23120135 | 0.91 | SMYD3 (0.87) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL13986292 | 0.91 | SMYD3 (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL23120131 | 0.91 | SMYD3 (0.87) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL19111317 | 0.91 | PRMT1 (1.00) | DOT1LPRMT1CARM1EHMT2WDR5 | |
| SCHEMBL23120193 | 0.90 | SMYD3 (0.84) | DOT1LPRMT1CARM1EHMT2WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465544-B2 | Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-12-16 | — | — | US | disclosed |
| US-20070161007-A1 | Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161007-A1 | Synthetic cofactor analogs of S-adenosylmethionine as ligatable probes of biological methylation and methods for their use | DNMT1, MAT2A, MAT1A | DOT1L 142/4885PRMT1 26/4885CARM1 118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.