Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 18/20 | 0.47 |
| ▸ | AXL | P30530 | 14/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348303 | 1.00 | MERTK (0.47) | MERTKAXLMETTYRO3GSK3B | |
| SCHEMBL13986941 | 1.00 | MERTK (0.47) | MERTKAXLMETTYRO3GSK3B | |
| SCHEMBL13987020 | 0.80 | GSK3B (0.48) | GSK3B | |
| SCHEMBL5236116 | 0.78 | GSK3B (0.52) | GSK3B | |
| SCHEMBL4848283 | 0.77 | GSK3B (0.51) | GSK3B | |
| SCHEMBL13986967 | 0.77 | DYRK1A (0.48) | GSK3B | |
| SCHEMBL14348307 | 0.77 | DYRK1A (0.48) | GSK3B | |
| SCHEMBL13986935 | 0.76 | SIGMAR1 (0.56) | — | |
| SCHEMBL5233639 | 0.76 | GSK3B (0.52) | GSK3B | |
| SCHEMBL5232508 | 0.76 | MAPK8 (0.55) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |