Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 5/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14348304 | 1.00 | ALDH1A1 (0.53) | ALDH1A1KDM4ERAB9ANPC1CHEK1 | |
| SCHEMBL5236116 | 0.84 | GSK3B (0.52) | ALDH1A1CHEK1GSK3BMKNK2ROCK2 | |
| SCHEMBL4848283 | 0.83 | GSK3B (0.51) | ALDH1A1KDM4EGSK3BMKNK2ROCK2 | |
| SCHEMBL5233639 | 0.82 | GSK3B (0.52) | ALDH1A1CHEK1GSK3BMKNK1MKNK2 | |
| SCHEMBL5232508 | 0.82 | MAPK8 (0.55) | GSK3BMKNK1MKNK2ROCK2 | |
| SCHEMBL13987020 | 0.80 | GSK3B (0.48) | ALDH1A1KDM4EGSK3BMKNK1MKNK2 | |
| SCHEMBL14348317 | 0.78 | GSK3B (0.45) | ALDH1A1RAB9ANPC1GSK3BBDKRB1 | |
| SCHEMBL13986936 | 0.78 | MAPK8 (0.51) | ALDH1A1KDM4EGSK3BMKNK1MKNK2 | |
| SCHEMBL4854586 | 0.77 | ROCK2 (0.52) | ALDH1A1RAB9ANPC1GSK3BROCK2 | |
| SCHEMBL13986968 | 0.77 | MAPK8 (0.50) | RAB9ANPC1GSK3BROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7462613-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |