Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5668175 | 0.94 | GSK3B (0.42) | GSK3BMKNK1MKNK2MAPK8NPC1 | |
| SCHEMBL4854586 | 0.85 | ROCK2 (0.52) | GSK3BNPC1RAB9AROCK2ROCK1 | |
| SCHEMBL13987004 | 0.80 | GSK3B (0.41) | GSK3BMKNK1MKNK2MAPK8HDAC1 | |
| SCHEMBL5232508 | 0.79 | MAPK8 (0.55) | GSK3BMKNK1MKNK2MAPK8HDAC1 | |
| SCHEMBL14348304 | 0.78 | ALDH1A1 (0.53) | GSK3BMKNK1MKNK2NPC1RAB9A | |
| SCHEMBL13986943 | 0.78 | ALDH1A1 (0.53) | GSK3BMKNK1MKNK2NPC1RAB9A | |
| SCHEMBL5236116 | 0.77 | GSK3B (0.52) | GSK3BMKNK2MAPK8HDAC1ROCK2 | |
| SCHEMBL5233639 | 0.77 | GSK3B (0.52) | GSK3BMKNK1MKNK2MAPK8HDAC1 | |
| SCHEMBL4854577 | 0.77 | GSK3B (0.49) | GSK3BMAPK8NPC1RAB9AHDAC1 | |
| SCHEMBL4848283 | 0.76 | GSK3B (0.51) | GSK3BMKNK2MAPK8ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |
| US-7309701-B2 | Pyridazinone derivatives as pharmaceuticals and pharmaceutical compositions containing them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-18 | — | — | US | disclosed |